Normal tissue complication probability modeling of radiation-induced bladder complications

Milad Baradaran-Ghahfarokhi


During radiation therapy for patients with prostate cancer, radiation exposure to non-target organs like the bladder remains unavoidable. The ultimate goal in prostate radiotherapy is to generate uncomplicated cures, i.e., maximizing tumor control probability (TCP) while at the same time minimizing the normal tissue complication probability (NTCP).
Considering a mixed serial–parallel behavior of the bladder, for NTCP modeling, various phenomenologic or empirical models can be used. However, the process of establishing dose/volume parameters being predictive for normal tissue morbidity following RT is likely to be influenced by the geometric uncertainties of the concerned organ.

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