Comparison of various theoretical methods on the effect of intermittent irradiation schedule

Safoora Nikzad, Bijan Hashemi, Hossein Mozdarani, Zuhair Mohammad Hassan


Modern radiotherapy techniques such as Intensity Modulated Radiation Therapy (IMRT), Respiratory-Gated, stereotactic, and Image Guide Radiotherapy (IGRT), enhance tumor local control and have lower radiation-induced toxicities in normal organs around the tumor compared to conventional techniques. Moreover, they vary in the dose delivery due to using more subfractions per each treatment fraction, different treatment times between subfractions, or the prolonged treatment time of one fraction. This study aimed to compare three different methods derived from the linear quadratic model which are used to estimate the effects of dose per subfraction, time intervals between subfractions, number of subfractions, and overall fraction time on the cell survival.

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